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Table 1 : Transcription factors (TF)

From Gene expression in stem cell-supporting stromal cell lines. (Ann N Y Acad Sci. 2005 Jun;1044:159-67. Charbord P, Moore K)

FunctionFamily*ProteinGene nameDetected in**Sequence§PW***StroCDB ID
neurogenesis and other differentiation processes (notch) HLH hairy enhancer of split-1 HES-1 DB, A em 2 LL6in11289T7
neurogenesis and other differentiation processes (notch) Groucho transducin-like enhancer of split 2 TLE2/GRG2 DB em LL6in12092T7
neurogenesis and other differentiation processes (notch) Groucho transducin-like enhancer of split 6 TLE6 DB em LL6in10664T7
neurogenesis and other differentiation processes (notch) Groucho amino enhancer of split AES/GRG DB em LL6in21090
neurogenesis and other differentiation processes (notch) mastermind-like 1 MAML1 DB homol LL6in21298
neurogenesis and other differentiation processes (notch) WD notchless protein - DB homol LL6in11661T7
craniofacial skeleton development (neural crest mesoderm) WH mesenchyme forkhead-1/Forkhead box protein C2 FOXC2/MFH1 A 7
craniofacial skeleton development (neural crest mesoderm) Hox paired-like homeodomain transcription factor 2/orthodenticle-like homeobox 2 PTX2/OTLX2/ARP1 DB em LL6in12271T7
neurogenesis and B-lymphopoiesis HLH olfactory-1/Early B-development Factor-like-2/Early B-cell factor 3 EBF3/COE3 DB, A em LL6in23243
craniofacial skeleton development (neural crest mesoderm) HLH olfactory-1/Early B-development Factor-like-3/Early B-cell factor 2 EBF2/COE2 DB em LL6in12046T7
mesoderm development ZFP odd-skipped related-1 protein OSR1 DB homol LL6in10832T7
craniofacial skeleton development (neural crest mesoderm) Hox paired mesoderm homeobox (pmx/mHox/rHox) PMX A
mesoderm development and hematopoiesis Hox DNA-binding protein Mel-18 MEL18/ZNF144 DB, A em LL6in20505
adipogenesis NR peroxisome proliferator activated receptor gamma PPARG DB em LL6in22535
adipogenesis NR peroxisome proliferator activated receptor delta/beta PPARD/PPARB DB em LL6in20408
adipogenesis NR peroxisome proliferator-activated receptor binding protein/thyroid receptor interacting protein 2 PPARBP or TRIP2 DB em LL6in20172
adipogenesis Hox homeobox protein Hox-C4/Hox 3.5 HOXC4 A
adipogenesis NR nuclear receptor ROR-gamma RORG DB em LL6in10911T7
NR orphan receptor TAK1/TR4 TR4 DB em LL6in20717
chondrogenesis HMG transcription factor SOX-9 SOX9 DB homol 7 LL6in20692
chondrogenesis HMG transcription factor SOX-5 SOX5 DB em LL6in10957T7
osteogenesis runt core-binding factor, alpha 1 subunit/Runt-related transcription factor 2 CBFA1/RUNX2/OSF2 GM 3, 9
ZFP zinc finger protein 38 ZNF38 DB em 9 LL6in12374M13R
HMG high mobility group protein HGM- Y HMGIY A 9
early-response gene and osteogenesis fos fos-related antigen -1 FRA1 DB, A em LL6in11627T7
early-response gene and osteogenesis fos fos-related antigen(fra)-2 FRA2 A
heart development ZFP zinc finger protein, multitype 2/friend of GATA-4 (FOG-2) ZFPM2/FOG2 DB em LL6in20637
heart development AP-1 transcription complex subunit NF-ATc4/NF-AT3 NFATC4/NFAT3 DB em LL6in11383T7
cardiovascular and muscle development MADS MADS box transcription enhancer factor 2, polypeptide D/myocyte enhancer factor 2D MEF2D DB em LL6in12267T7
cardiovascular and muscle development FHL Four and a Half LIM (FLH) protein-1/Skeletal muscle LIM-protein 1 FLH1 A
cardiovascular and muscle development FHL Four and a Half LIM (FLH) protein-2/ Skeletal muscle LIM-protein 3 FLH2 A
early-response gene and muscle differentiation MADS serum response factor SRF DB em LL6in10489T7
hematopoiesis ZFP basic Kruppel-like factor/Kruppel-like factor 3 BKLF/KLF3 DB em LL6in10277T7
hematopoiesis ZFP ecotropic virus integration 1 site protein EVI1 DB em LL6in22478
hematopoiesis Hox homeobox protein Meis2 MEIS2 A
hematopoiesis myb B-myb oncogene/myeloblastosis oncogene-like 2 BMYB/MYBL2 DB em LL6in22378
hematopoiesis myb myb-related protein A AMYB/MYBL1 A
angiogenesis / vasculogenesis HLH arylhydrocarbon receptor nuclear translocator ARNT DB, A em LL6in10436T7
angiogenesis / vasculogenesis ZFP vascular endothelial zinc finger-1 VEZF1 DB em LL6in20954
pancreatic islet § cell development (endoderm) Hox paired box protein Pax-4 PAX4 A

* HLH : helix loop helix; WH : winged helix; Hox : homeobox; ZFP : zing finger protein; NR : nuclear receptor; HMG : high mobility group; WD : WD protein

** DB : StroCDB (database AFT024-2018) at http://stromalcell.princeton.edu; A : Affimetrix chips; GM : GM chips

*** PW : already given in previous works on gene product screening using stromal cells (shown in italic):

§ for gene products in the database: em = exact match; homol = homolog

1. Dieudonne SC, Kerr JM Xu T et al. Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasone.J Cell Biochem. 1999;76 : 231-43.

2. Locklin RM, Riggs BL, Hicok KC et al. Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. J Bone Miner Res. 2001; 16 : 2192-204.

3. Tremain N, Korkko J, Ibberson D et al. MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells. 2001; 19 :408-18.

4. Jia L, Young MF, Powell J et al. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Genomics. 2002; 79 : 7-17

5. Doi M, Nagano A, Nakamura Y. Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochem Biophys Res Commun. 2002; 290 : 381-90

6. Graf L, Iwata M, Torok-Storb B. Gene expression profiling of the functionally distinct human bone marrow stromal cell lines HS-5 and HS-27a. Blood. 2002; 100 : 1509-11.

7. Sekiya I, Vuoristo JT, Larson BL, Prockop DJ. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci U S A. 2002; 99 : 4397-402.

8. Wieczorek G, Steinhoff C, Schulz R et al. Gene expression profile of mouse bone marrow stromal cells determined by cDNA microarray analysis. Cell Tissue Res. 2003; 311 : 227-37.

9. Qi H, Aguiar DJ, Williams SM et al. Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells. Proc Natl Acad Sci U S A. 2003; 100 : 3305-10.


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