StroCDB Home
Introduction Methods Web-only Data Figures Classification Search BLAST

Table 3 : Cytoskeleton

From Gene expression in stem cell-supporting stromal cell lines. (Ann N Y Acad Sci. 2005 Jun;1044:159-67. Charbord P, Moore K)

LL6in10279T7
Class*ProteinGene nameDetected in**Sequence§PW***StroCDB ID
AF alpha-cardiac actin ACTC1 A 2
AF bradykinin B2 receptor BDKRB2 DB em
AF lysophosphatidic acid (LPA) receptor EDG4 A 9
AF cdc42 GTPase CDC42 A
AF rho A GTPase RHOA A
AF RHO7/RHON A
AF activation of cdc42, rac ARHGEF7/PAK3BP DB em LL6in11479T7
AF binder of Rho GTPases (Borg) family BORG DB em LL6in22554
AF Homer/Wiskott Aldrich Syndrome protein (WASP) homolog HOMER DB homol LL6in10803T7
AF cdc42-interacting protein 4 CIP4 DB homol LL6in10408T7
AF plenty of SH3 POSH DB em LL6in12368M13R
AF rac GTPase-activating protein 1 RACGAP1 DB em LL6in20065
AF Sh3 binding protein-1 SH3BP1 DB em LL6in21551
AF lfc oncogene/GEF-H1 ARHGEF2 A
AF Guanine nucleotide exchange factor DBS DBS DB em LL6in22868
AF guanine nucleotide dissociation inhibitor GDI-2/D4 GDID4/ARHGDIB DB, A em LL6in22522
AF rho-associated, coiled-coil forming protein kinase p160 ROCK-2 ROCK2 A
AF aortic preferentially expressed protein 1 APEG1 DB em C51
AF LIM kinase 2 (a/b) LIMK2A DB em LL6in10467T7
AF Lim domain kinase 1 LIMK1 DB em 9 LL6in10362T7
AF rhotekin RTKN DB em LL6in20879
AF protein kinase C-like PKN PKN/PRKCL1 DB homol LL6in11152T7
AF related adhesion focal tyrosine kinase RAFTK/FAK2 DB em LL6in22111
AF vinexin/SH3-containing adaptor molecule 1 SCAM-1 DB em 9 LL6in21631
AF hydrogen peroxide-inducible protein (hic-5) HIC5 DB em LL6in20153
ABP chaperonin containing TCP-1 zeta subunit CCTZ DB em LL6in11200T7
ABP adenylyl cyclase-associated protein 1 CAP1 DB em LL6in11731T7
ABP adenylyl cyclase-associated protein 2 CAP2 DB homol D87
ABP gelsolin GSN DB em 5 LL6in11648T7
ABP CapG/Macrophage capping protein/ Myc basic motif homologue-1 CAPG/MBH1 A
ABP calpain 2 CAPN2 A 5
ABP calpain 4 CAPN4 A
ABP calpain 10 CAPN10 DB em C75
ABP profilin 2 PFN2 GM 9
ABP fascin FSCN1 DB em LL6in20352
ABP acidic calponin 3 CNN3 DB homol LL6in11247T7
ABP alpha-actinin 1 ACTN1 A
ABP huntington interacting protein 1 HIP1 DB homol LL6in12293T7
ABP filamin FLN A, GM
ABP gamma adducin ADD3/ADDL DB homol LL6in11332T7
ABP brain beta-spectrin SPTB2 A
ABP neuromodulin/growth accentuating protein 43 GAP43 DB, A em LL6in11355T7
ABP annexin III ANX3 DB em LL6in11201T7
ABP annexin IV ANX4 A
ABP annexin VI ANX6 A 1
ABP cortactin CTTN A
ABP FERM, RhoGEF and pleckstrin domain protein 2 FARP2 DB em 6 LL6in11075T7
ABP moesin MSN A
ABP protein tyrosine phosphatase 36 PTPN14 DB em LL6in11828T7
ABP protein tyrosine phosphatase MEG1 PTPN4 A
ABP scaffold/motor for signalling complexes septin 6 SPT6 A
ABP caveolin CAV A
ABP src-suppressed C-kinase substrate SSECKS GM
ABP 65 K Yes-associated protein YAP65 A
ABP 43kDa acetylcholine receptor-associated protein RAPSN DB em LL6in20855
ABP contractility and isometric tension adult skeletal muscle myosin heavy chain/MHC2B MYH4 A
ABP alpha cardiac myosin heavy chain MYH6/MYHCA A
ABP nonmuscle myosin heavy chain-A MYH9 DB homol LL6in11249T7
ABP myosin light chain 3 MYL6 A 8
ABP binding to A and membrane lipids myosin I b MYO1B A
ABP myosin I beta/myosin I c MYO1C DB, A em LL6in10463T7
ABP MysPDZ MYSPDZ DB em LL6in11315T7
IF keratin A, type I cuticular KRTHA1 DB, A em LL6in11591T7
IF cytokeratin 19 KRT19 DB em LL6in10453T7
IF lamin B2 LMNB2 DB em LL6in12205T7
IF plectin 1 PLEC1 DB homol 5 LL6in21287
IF plakophilin 2 (a/b) PKP2 DB homol LL6in10219T7
IF/MT gamma synuclein SNCG A
MT alpha tubulin isotype M-alpha-2 TUBA DB em 4 LL6in10716T7
MT alpha-tubulin isotype M-alpha-4 TUBA A 4
MT gamma-tubulin complex component 1 TUBG1/TUBG DB LL6in10824T7
MT gamma tubulin complex component 2 GCP2 DB homol LL6in20520
MT dynein heavy chain DYHC A 9
MT dynactin 150 Kd DCTN1 A
MT kinesin-like protein 68D KLP68D A
MT kinesin family member KIF1B KIF1B DB em LL6in11107T7
MT kinesin family member KIF2§ KIF2BETA DB em LL6in11134T
MT kinesin family member KIF3C KIF3C DB em LL6in20022
MT kinesin family member KIF7 KIF7 DB em LL6in11857T7
MT tubulin-specific chaperone e TBCE DB homol LL6in12054T7
MT retinitis pigmentosa 2 (X-linked recessive) RP2 DB homol LL6in11393T7

* Abbreviations:
    AF: Actin microfilaments
    ABP: actin-binding protein
    FIL: filopodia formation
    LAM: lamellipodia
    FA/SF: focal adhesion/stress fiber
    AFA: actin filament assembly
    A/M link: AF to cytoplasmic membrane link
    IF: intermediate filament
    MT: microtubule

** DB : StroCDB (database AFT024-2018) at http://stromalcell.princeton.edu; A : Affimetrix chips; GM : GM chips

*** PW : already given in previous works on gene product screening using stromal cells (shown in italic):

§ for gene products in the database: em = exact match; homol = homolog

1. Dieudonne SC, Kerr JM Xu T et al. Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasone.J Cell Biochem. 1999;76 : 231-43.

2. Locklin RM, Riggs BL, Hicok KC et al. Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. J Bone Miner Res. 2001; 16 : 2192-204.

3. Tremain N, Korkko J, Ibberson D et al. MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells. 2001; 19 :408-18.

4. Jia L, Young MF, Powell J et al. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Genomics. 2002; 79 : 7-17

5. Doi M, Nagano A, Nakamura Y. Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochem Biophys Res Commun. 2002; 290 : 381-90

6. Graf L, Iwata M, Torok-Storb B. Gene expression profiling of the functionally distinct human bone marrow stromal cell lines HS-5 and HS-27a. Blood. 2002; 100 : 1509-11.

7. Sekiya I, Vuoristo JT, Larson BL, Prockop DJ. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci U S A. 2002; 99 : 4397-402.

8. Wieczorek G, Steinhoff C, Schulz R et al. Gene expression profile of mouse bone marrow stromal cells determined by cDNA microarray analysis. Cell Tissue Res. 2003; 311 : 227-37.

9. Qi H, Aguiar DJ, Williams SM et al. Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells. Proc Natl Acad Sci U S A. 2003; 100 : 3305-10.


Copyright © 2005 Princeton University