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Table 6 : Cytokines and Chemokines

From Gene expression in stem cell-supporting stromal cell lines. (Ann N Y Acad Sci. 2005 Jun;1044:159-67. Charbord P, Moore K)

ClassFunction/NatureProteinGene nameDetected in**Sequence§PW***StroCDB ID
Chemokine CC-chemokine monocyte chemoattractant protein-1/JE protein MCP-1/CCL2 DB em 2 LL6in11607T7
Chemokine CXC-chemokine growth regulated oncogene-a/melanoma growth stimulatory activity GR01/MGSA/CXCL1 A 6
Chemokine CXC-chemokine LPS-induced CXC chemokine/small inducible cytokine B5 SCIB5 DB em LL6in21735
Chemokine CXC-chemokine stromal cell derived factor 1 SDF-1/CXCL12 GM 3, 6, 8
Chemokine CXC3-chemokine fractalkine/neurotactin FKN/CX3CL1 DB em LL6in11199T7
Cytokine hematopoietic, stromal cytokine insulin-like growth factor IGF DB homol
Cytokine hematopoietin leukemia inhibitory factor LIF DB em LL6in20669
Cytokine hematopoietin stem cell factor (SCF) KITL/SL/SLF DB em B09
Cytokine Epidermal GF (EGF) family transforming growth factor (TGF)-alpha TGFA DB em LL6in11006T7
Cytokine Epidermal GF (EGF) family neuregulin 1/Neu differentiation factor NRG1/NDF DB homol LL6in20071
Cytokine TGF§ family pleiotrophin PTN DB, A, GM em LL6in10322T7
Cytokine TGF§ family growth/differentiation factor-10/bone morphogenetic protein-3B BMP3B DB em LL6in11474T7
Cytokine TGF§ family growth/differentiation factor -15 GDF15 DB em F77
Cytokine angiogenic cytokine vascular endothelial growth factor (VEGF) VEGF/VEGFA A 4, 7, 8
Cytokine angiogenic cytokine placental growth factor PLGF DB em 2 LL6in10739T7
Cytokine angiogenic cytokine angiopoietin-3 ANG3 DB homol LL6in20550
Cytokine angiogenic cytokine extra cellular matrix protein 1 ECM1 GM 3, 7
Cytokine angiogenic cytokine platelet-derived endothelial growth factor/thymidine phosphorylase ECGF1 DB em A79
Cytokine fasting induced adipose factor/angiopoietin-like 4 FIAF/ANGPTL4 DB em LL6in10752T7
Cytokine prolactin family proliferin PLF DB, A em LL6in20191
Cytokine prolactin family prolactin-like protein F PRLPF A
TGF§-inducible protein/follistatin-like 1 TSC36/FSTL DB, GM em LL6in20015
Receptor (R) § chemokine R MCP-1 receptor CCR2 A
Receptor (R) § chemokine R beta chemokine receptor D6 D6 DB em LL6in11204T7
Receptor (R) Cytokine Receptor family growth hormone receptor GHR DB em 8 LL6in21098
Receptor (R) Cytokine Receptor family interleukin 6 receptor IL6R DB homol LL6in21418
Receptor (R) Receptor tyrosine kinase (RTK) neu/c-ErbB2 p185 NEU/ERBB2/HER2 DB homol LL6in11220T7
Receptor (R) Receptor tyrosine kinase (RTK) neurotrophin receptor tyrosine kinase (RTK) type 3 NTRK3 GM 3
Receptor (R) Receptor tyrosine kinase (RTK) ufo receptor tyrosine kinase/Axl oncogene UFO/AXL/AKR DB em D46
Receptor (R) pleiotrophin ligand syndecan-3 SDC3 A 8
Receptor (R) TGF§R family transforming growth factor (TGF)-beta receptor I SKR4 DB em LL6in11923T7
Receptor (R) TGF§R family bone morphogenetic protein type II receptor (BMPR-II) BMPR2 DB em LL6in20364
Receptor (R) class II cytokine receptor interferon (IFN) gamma receptor beta subunit IFNGR2 DB em LL6in10790T7
Receptor (R) class II cytokine receptor class II cytokine receptor 4 CRFB4/IL10RB DB em LL6in20194
Receptor (R) TNFR family tumor-necrosis factor (TNF) receptor I TNFRSF1B/TNFR2 DB em LL6in10816T7
Receptor (R) TNFR family lymphotoxin-§ receptor TNFRSF3/LTBR DB em 5 LL6in11768T7
Receptor (R) TNFR family 41BB ligand/TNF receptor superfamily member 9 TNFRSF9 DB em
Modulator IGF-1R modulation IGF-binding protein-3 IGFBP3 DB homol 3, 6 LL6in20358
Modulator IGF-1R modulation IGF-binding protein-5 IGFBP5 DB em 7 LL6in11214T7
Modulator IGF-1R modulation IGF-binding protein-6 IGFBP6 DB, A em LL6in20956
Modulator insulin/IGF-1/TGFa degradation insulin-degrading enzyme IDE DB em F89
Modulator RTK endocytosis ral guanine nucleotide dissociation stimulator-like 1 RGL/RGL1 DB em LL6in10634T7
Modulator RTK endocytosis ral guanine nucleotide dissociation stimulator/ralGEF RALGDS DB em LL6in10363T7
RTK endocytosis sorting nexin 1 SNX1 A 3
RTK endocytosis sorting nexin 12 SNX12 DB em E66
RTK endocytosis sorting nexin 15 SNX15 DB homol LL6in10439T7
Transducer TGF§/BMP R signalling TGF-beta-activated kinase 1 (TAK1) binding protein-1 TAB1 DB homol LL6in10627T7
Transducer TGF§/BMP R signalling mothers against DPP homolog 7/smad7 MADH7/SMAD7 DB em 2 LL6in11399T7
Transducer TGF§/BMP R signalling transducer of ErbB-2 TOB DB em LL6in11198T7
Transducer FGFR signalling fibroblast growth factor (FGF) inducible gene 15 FIN15 A
Transducer FGFR signalling acid-FGF intracellular binding protein FIBP DB homol LL6in20354
Transducer FGFR signalling suc1-associated neurotrophic factor target-2 SNT2 DB homol LL6in10019T7
Transducer IFNR signalling p52 restoring inhibition of protein kinase RNA-dependent P52RIPK DB homol LL6in10589T7
Transducer activation of IFN-responsive genes interferon regulatory factor 3 IRF3 DB em LL6in22008
Transducer activation of IFN-responsive genes interferon regulatory factor 5 IRF5 DB em 6 D70
Transducer IL-1R signalling mouse Pelle-like protein kinase/IL-1 receptor-associated kinase IRAK1 DB em LL6in21855
Transducer IL-1R signalling evolutionarily conserved signaling intermediate in Toll pathways ECSIT DB em LL6in20929
Transducer IL-1R signalling MAPK-activated protein kinase 5 MAPAPK5 DB em LL6in10606T7
Transducer IL-1/TNF R signalling MAPK/ERK kinase kinase 1 MEKK1/MAP3K1 DB em LL6in21767
Transducer IL-1/TNF R signalling mitogen-activated protein (MAP) kinase 38§ MAPK11 DB em LL6in11211T7
Transducer IL-1/TNF R signalling tumor necrosis factor receptor-associated factor 4 TRAF4/CART1 DB em LL6in11817T7
Transducer IL-1/TNF R signalling phosphoprotein enriched in astrocytes-15 kD PEA-15 A 9
Transducer IL-1/TNF R signalling nuclear factor kappa B subunit p100 NFKB2 A
Transducer IL-1/TNF R signalling c-Jun N-terminal kinase 2 MAPK9/JNK2 DB em B72
Transducer insulin/IGF signalling insulin receptor substrate tyrosine kinase substrate IRS1 DB homol 9 LL6in20725
Transducer insulin/IGF signalling growth factor receptor-binding protein (Grb10) GRB10 A

* HLH : helix loop helix; WH : winged helix; Hox : homeobox; ZFP : zing finger protein; NR : nuclear receptor; HMG : high mobility group; WD : WD protein

** DB : StroCDB (database AFT024-2018) at http://stromalcell.princeton.edu; A : Affimetrix chips; GM : GM chips

*** PW : already given in previous works on gene product screening using stromal cells (shown in italic):

§ for gene products in the database: em = exact match; homol = homolog

1. Dieudonne SC, Kerr JM Xu T et al. Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasone.J Cell Biochem. 1999;76 : 231-43.

2. Locklin RM, Riggs BL, Hicok KC et al. Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. J Bone Miner Res. 2001; 16 : 2192-204.

3. Tremain N, Korkko J, Ibberson D et al. MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells. 2001; 19 :408-18.

4. Jia L, Young MF, Powell J et al. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Genomics. 2002; 79 : 7-17

5. Doi M, Nagano A, Nakamura Y. Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochem Biophys Res Commun. 2002; 290 : 381-90

6. Graf L, Iwata M, Torok-Storb B. Gene expression profiling of the functionally distinct human bone marrow stromal cell lines HS-5 and HS-27a. Blood. 2002; 100 : 1509-11.

7. Sekiya I, Vuoristo JT, Larson BL, Prockop DJ. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci U S A. 2002; 99 : 4397-402.

8. Wieczorek G, Steinhoff C, Schulz R et al. Gene expression profile of mouse bone marrow stromal cells determined by cDNA microarray analysis. Cell Tissue Res. 2003; 311 : 227-37.

9. Qi H, Aguiar DJ, Williams SM et al. Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells. Proc Natl Acad Sci U S A. 2003; 100 : 3305-10.


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